新萄京网址33522

 

师资队伍

师资队伍
师资队伍

于洋

副研究员

 

邮箱:yuyang2011@sjtu.edu.cn
主页:联系地址:上海交通大学生物药学楼6号楼510室

于洋,女,副研究员。上海交通大学“SMC-晨星青年学者奖励计划“A类支持计划(2019年度)。

博士就读于中国科学院上海药物研究所,师从金国章院士及镇学初教授,致力于神经退行疾病的机制研究。2007年博士毕业后赴美国纽约州立基础研究所进行博士后学习,而后回国于2011年就职于新萄京网址33522。

课题研究的方向为神经免疫药理学及肿瘤药理学,包括神经退行性疾病的机制研究和靶点发现,即炎症因子及受体在阿尔茨海默病中的作用及机制研究;及肿瘤的发病机制探究,如炎症因子及受体在结直肠癌发生发展中的作用。

研究成果发表在相关领域的高质量杂志上(以第一作者及通讯作者发表多篇高质量SCI文章,如神经领域顶级期刊Journal of Neuroscience、Journal of Neuroinflammation等)。应邀撰写综述并有较高的被引率,于2019年担任专业领域SCI杂志(Journal of Alzheimer's Disease)副主编,在领域内具有一定的学术影响力。培养了多名优秀的博士及硕士毕业生。
神经退行性疾病发病机制研究及靶点发现。
Haibo Zhang, Aihua Lin, Ping Gong, Yanqing Chen, Richard D Ye, Feng Qian, Yan Zhang, Yang Yu*. The chemokine-like receptor 1 deficiency improves cognitive deficits of AD mice and attenuates tau hyperphosphorylation via regulating tau seeding. J Neurosci. 2020 Aug 12:JN-RM-0455-20. doi: 10.1523/JNEUROSCI.0455-20.2020. Online ahead of print.

Aihua Lin, Jin Liu, Ping Gong, Yanqing Chen, Haibo Zhang, Yan Zhang, Yang Yu*. Serum amyloid A inhibits astrocyte migration via activating p38 MAPK. J Neuroinflammation. 2020 Aug 29;17(1):254. doi: 10.1186/s12974-020-01924-z.

Haibo Zhang, Ding Wang, Ping Gong, Aihua Lin, Yan Zhang, Richard D Ye, Yang Yu*. Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2019;67(1):169-179.

Shuqin L, Ning Su, Ping Gong, Haibo Zhang, Jin Liu, Ding Wang, Yanping Sun, Yan Zhang, Feng Qian, Bo Zhao, Yang Yu*, Richard D Ye*. The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer. Sci Rep. 2017 Jul 19;7(1):5918.

Jin Liu, Ding Wang, Shuqin Li, Yang Yu*, Richard D Ye*. Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A. J Neuroinflammation. 2016 Feb 2;13:28. doi: 10.1186/s12974-016-0493-y.

Shuqin Li#, Yang Yu#, Jinzhao Han, Ding Wang, Jin Liu, Feng Qian, Guohuang Fan, Richard Bucala, Richard D Ye. Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease. J Neuroinflammation. 2015 Sep 17;12:177. doi: 10.1186/s12974-015-0396-3.

Yang Yu #*, Richard D. Ye. Microglial Aβ receptors in Alzheimer's disease. Cell Mol Neurobiol. 2015 Jan;35(1):71-83. doi: 10.1007/s10571-014-0101-6. Epub 2014 Aug 23.

Yang Yu, Xiaojing Li, Blanchard Julie, Yi Li, Khalid Iqbal, Fei Liu, and Chengxin Gong. Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice. 2014 J Neural Transm. 2014 Aug 13

Lei Peng#, Yang Yu#, Jin Liu, Shuqin li, Huiqiong He, Ni Cheng, Richard D. Ye. (2014) The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide. J Alzheimers Dis. 2014 Jul 30.

Yang Yu, Jin Liu, Shuqin li, Lei Peng, Richard D, Ye. (2014) Serum amyloid A differentially activates microglia and astrocytes via the PI3K pathway. J Alzheimers Dis. 2014; 38(1): 133-44.

Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H. Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J. Vocadlo, Fei Liu, Cheng-Xin Gong. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PLoS ONE. 2012; 7(4):e35277

Yang Yu, Xiao-Qin Run, Zhi-Hou Liang, Yi Li, Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal and Cheng-Xin Gong. Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. J Neurochem. 2009; 108 (6): 1480-94.

Yang Yu, Jing-Ru Wang, Pei-Hua Sun, Yang Guo, Zhang-Jin Zhang, Guo-Zhang Jin and Xue-Chu Zhen. Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor dependent inhibition of glycogen synthase kinase-3β and a receptor independent anti-oxidative action. J Neurochem. 2008; 104 (4): 946-56.
自2011年入职上海交通大学至今,共主持国家自然科学基金项目三项,一项国自然青年项目(2012年)及两项国自然面上项目(2015年及2018年);主持教育部高等学校博士点专项基金(新教师类)一项(2012年)。
© 2020 新萄京网址33522

新萄京网址33522
地址:上海市东川路800号
邮编:200240