新萄京网址33522

 

师资队伍

师资队伍
师资队伍

朱明彦

讲师

 

电话:34206991
邮箱:myzhu@sjtu.edu.cn
主页:地址:新萄京网址335227号楼506室

教育背景

Ph.D. Organic Chemistry, Seoul National University, South Korea, 2012.
M.S. Organic Chemistry, Myong Ji University, South Korea, 2006.
B.S. Chemistry, Wuhan University, China, 2004.

工作和研究经历:
2013年4月-至今:新萄京网址33522, 讲师,硕士生导师

主持课题:
1. 国家自然科学基金青年项目,21402118,半胱氨酸天冬氨酸蛋白酶-1光控分子开关的设计与合成,25万,2015/01-2017/12,已结题
2. 上海市自然科学基金,17ZR1449000,siRNA的分子开关和基因表达的光调控,20万,2017/05-2020/04,已结题
3. 上海交通大学医工交叉基金,新型SIRT1激活剂E4023改善脂质代谢紊乱的机理研究,2018/01-2020/12,在研
4. 上海交通大学医工交叉基金,Incarvine C调控ROCK抑制肝癌细胞株增殖与血管化拟态形成,2015/01-2017/12,已结题
药物化学,化学生物学
以活性小分子为工具对生物大分子的功能揭示和调控:1. 以具有生物活性的小分子为探针进行药物靶点发现和验证。2. 利用光控分子开关进行生物大分子活性的调控:蛋白的光控抑制剂,光控小干扰RNA。
[1] Weixiang Xin,# Zezhong Li,# Qing Wang, Jin Du, Mingyan Zhu, Huchen Zhou* Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors. Eur. J. Med. Chem. 2020, 185,111827. (IF=5.572)
[2] Zhihua Ge, Zhuojin Yang, Jingshi Liang, Duoling Dong, Mingyan Zhu* Optical Control of GTP Affinity of K-Ras(G12C) by Photoswitchable Inhibitor. ChemBioChem 2019, 20,2916 –2920. (IF=2.774)
[3] Jiong Zhang,# Jinyi Zhang,# Guiyun Hao, Weixiang Xin, Fei Yang, Mingyan Zhu, Huchen Zhou* Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. J. Med. Chem. 2019, 62, 14, 6765–6784. (IF=6.253)
[4] Bo Li, Xiaopeng Hu, Yanzhou Yang, Mingyan Zhu, Jiong Zhang, Yanrong Wang, Xiuying Pei, Huchen Zhou*, Ji Wu* GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro. Mol. Ther. Nucleic Acids 2019, 17, 436-447. (IF=7.032)
[5] Xinyue Li, Xiaopeng Hu, Geng G. Tian, Ping Cheng, Zezhong Li, Mingyan Zhu, Huchen Zhou,* and Ji Wu* C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro. Cells 2019, 8(6), 606 (IF=4.829)
[6] Mingyan Zhu, Huchen Zhou* Azobenzene-based small molecular photoswitches for protein modulation. Org. Biomol. Chem. 2018, 16(44), 8434–8445. (IF=3.423)
[7] Fei Yang, Mingyan Zhu, Jinyi Zhang, Huchen Zhou* Synthesis of biologically active boron-containing compounds. MedChemComm. 2017, 9(2), 201–211. (IF=2.342)
[8] Zhongli Wang, Wenjuan Xie, Mingyan Zhu, Huchen Zhou* Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors. Bioorg. Med. Chem. Lett. 2017, 27(17), 4015–4018. (IF=2.442)
[9] Jiong Zhang, Fei Yang, Zhitao Qiao, Mingyan Zhu, Huchen Zhou* Chalcone-benzoxaborole hybrids as novel anticancer agents. Bioorg. Med. Chem. Lett., 2016, 26(23), 5797–5801. (IF=2.442)
[10] Jiong Zhang, Mingyan Zhu, Yinan Lin, Huchen Zhou* The synthesis of benzoxaboroles and their applications in medicinal chemistry. Sci. China Chem., 2013, 56(10), 1372–1381. (IF= 4.448)
[11] Mingyan Zhu, Byung Joon Lim, Minseob Koh, Seung Bum Park* Construction of polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway: part II. ACS Comb. Sci., 2012, 14(2), 124–134. (IF=3.408)
[12] Mingyan Zhu, Myung Hee Kim, Sanghee Lee, Su Jung Bae, Seong Hwan Kim*, Seung Bum Park* Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand. J. Med. Chem., 2010, 53(24), 8760–8764. (IF=5.207)
<公开专利>
1. 朱明彦, 东多凌, 葛志华, 杨卓进, 梁婧诗. 一种乙酰氨基偶氮苯类衍生物及其制备与应用. (CN109574871A,已公开,公开日 2019.4.5)
2. Huchen Zhou, Jiong Zhang, Mingyan Zhu, Long Ye, Yiqing Feng. Preparation of 7-propanamide substituted benzoxaboroles and their use as anticancer agents. (已申请,申请号 PCT/CN2018/076426)
3. 周虎臣, 张煚, 杨斐, 林轶男, 朱明彦. 一种苯并硼唑7位查尔酮衍生物及其制备与应用. (CN108191898B,已授权,授权日 2020.8.25)
4. 周虎臣, 张煚, 朱明彦, 叶龙, 冯怡卿. 一种苯并硼唑7位脂肪酸的衍生物及其制备与药物用途. (CN107090000B,已授权,授权日 2019.7.12)
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