新萄京网址33522

 

师资队伍

师资队伍
师资队伍

金慧子

研究员

 

电话:(86)-021-34205989
邮箱:kimhz@sjtu.edu.cn
主页:7号楼 201-204室

金慧子研究员简介
女,研究员,博士生导师。2004年毕业于韩国忠南大学药科大学,获得药学博士学位。2004年12月回国后在中科院上海药物研究所工作。2006年至今在新萄京网址33522从事科研与教学工作。主要从事具有新颖结构的生物活性天然产物的研究。主要的研究兴趣为活性显著的天然先导化合物的发现及中药的质量控制。申请人研究了超过50多种中草药,特别是系统地研究了15种中国产旋覆花属植物药效物质基础,基本阐明该属植物的药效成分。已经完成一项国家重大专项,一项国家自然基金青年项目,和2项上海市科委项目。目前承担一项上海市科委基金项目。近年来,共发表科研论文100多篇,其中SCI论文近80篇,发表在天然产物领域著名的杂志Chemical Communications, Organic Letters, Journal of Natural Products, Tetrohedron, Phytochemisty, Planta Medica上。申请专利9项。
主持完成国家科技重大新药创制专项、国家自然科学基金、上海市科委中药现代化专项基金等项目。
联系方式:021-34205989;kimhz@sjtu.edu.cn
主要研究方向
1、生物活性导向下的中药化学成分分离,结构鉴定与修饰
2、中药质量控制新方法研究
3、中药与民族物新药的研究与开发
4、功能性天然产物研究/化妆品
Selected Publications:
1. Syed Shams ul Hassana, Hui-zi Jin#, Tareq Abu-Izneid, Abdur Rauf, Muhammad Ishaq, Hafiz Ansar Rasul Suleriada. Stress-driven discovery in the natural products: A gateway towards new drugs. Biomedicine & Pharmacotherapy. 109: 459-467 (2019).
2. Yi-Gong Guo, Yang-Guo Xie, Guo-Jing Wu, Tao-Fang Cheng, Sheng-Lan Zhu, Shi-Kai Yana, *, Hui-Zi Jin*, Wei-Dong Zhang*. Xylopidimers A-E, five new guaiane dimers with various carbon skeletons from the roots of Xylopia vielana. ACS Omega,4:2047-2052 (2019).
3. Jie Ren, Yang-guo Xie ,Yi-gong Guo, Sheng-lan Zhu, Hui-zi Jin*, Wei-dong Zhang*. Unusual metal complex of cadinane sesquiterpene alkaloid and new neolignan glycosides from Alangium alpinum. Fitoeterapia, 125:18-23 (2018).
4. Jie Ren, Chao Fan, Yi-Gong Guo, Shi-Kai Yan, Richard D Ye, Yan Zhang, Huizi Jin*, Weidong Zhang*. New biphenantherene and nervogenic acid derivatives from Liparis regnieri Finet and inhibitory acivities against NF-B activation. Tetrahedron, 73: 1611-1617 (2017).
5. Yu Zhang, Xin-cai Zhao, Yang-guo Xie, Chao Fan, Ying-ying Huang, Shi-kai Yan, Yan Zhang, Hui-zi Jin*, Wei-dong Zhang*. Eight new γ-lactam alkaloids from the roots of the Hemerocallis minor Mill. Fitoterapia, 118:80-86 (2017).
6. Yang-Guo Xie, Tao Li, Guo-Wei Wang, Jie Ren, Xing Wang, Ya-Ping Pan, Hui-Liang Li, Shi-Kai Yan, Hui-Zi Jin*, Wei-Dong Zhang*. Chemical constituents with antibacterial activities from Campylotropis hirtella. Plnata Med. 82: 734-741 (2016).
7. Yue Zheng, Yang-Guo Xie, Yu Zhang, Tao Li, Hui-Liang Li, Shi-Kai Yan, Hui-Zi Jin*, and Wei-Dong Zhang*. New norlignans and flavonoids of Dysosma versipellis. Phytochemistry letters 16 (75-81) (2016).
8. Yong-li Li, Yan-xia Gao, Hui-zi Jin, Lei Shan, Wan-lin Chang, Xian-wen Yang, Hua-wu Zeng, Ning Wang, Andre Steinmetz, Wei-dong Zhang. Chemical constituents of Abies fabri. Phytochemistry. 117: 135-143 (2015).
9. Guo-Wei Wang, Jiang-Jiang Qin, Xiang-Rong Cheng, Yun-Heng Shen, Lei Shan, Hui-Zi Jin* & Wei-Dong Zhang*. Inula sesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity. Expert Opin. Investig. Drugs 23(3): 317-345 (2014).
10. Jie Ren, Yuanyuan Zhang, Huizi Jin*, Jing Yu, Yueyang Zhou, Fang Wu, and Weidong Zhang. Novel Inhibitors of Human DOPA Decarboxylase Extracted from Euonymus glabra Roxb. ACS Chem. Biol. 9, 897−903 (2014).
11. Xiang-Rong Cheng, Chun-Hui Wang, Pan-Lei Wei, Xu-Feng Zhang, Qi Zeng, Shi-Kai Yan, Hui-Zi Jin*, Wei-Dong Zhang. New sesquiterpenic acids from Inula wissmanniana. Fitoterapia 95:139–146 (2014).
12. Bin Guan, Tao Li, Xi-Ke Xu, Xu-Feng Zhang, Pan-Lei Wei, Cheng-Cheng Peng, Jian-Jun Fu, Qi Zeng a, Xiang-Rong Cheng, Shou-De Zhang, Shi-Kai Yan, Hui-Zi Jin,* Wei-Dong Zhang. -Hydroxynitrile glucosides from the seeds of Prinsepia utilis. Phytochemistry 105: 135–140 (2014).
13. Yong-Li Li, Yan-Xia Gao, Hui-Zi Jin, Lei Shan, Xue-Song Liang, Xi-Ke Xu, Xian-Wen Yang Ning Wang, Andre Steinmetz, Zhilei Chen, Wei-Dong Zhang. Chemical constituents of Abies nukiangensis. Phytochemistry 106: 116–123 (2014).
14. Shuang Liang, Shan-Xiang Liu, Hui-Zi Jin, Lei Shan, Shi-Chong Yu, Yun-Heng Shen, Hui-Liang Li, Qiu-Ye Wu, Qing-Yan Sun and Wei-Dong Zhang. Two novel innovanoside dimers from Daphne aurantiaca and a concise total synthesis of diinnovanoside A. Chem. Commun., 49, 6968—6970 (2013).
15. Xiang-Rong Cheng, Shou-De Zhang, Chun-Hui Wang, Jie Ren, Jiang-Jiang Qin, Xue Tang, Yun-Heng Shen, Shi-Kai Yan, Hui-Zi Jin*, Wei-Dong Zhang. Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz. Phytochemistry 96: 214–222 (2013).
16. Hu Yuan, Kai-Jian Bi, Bo Li, Rong-Cai Yue, Ji Ye, Yun-Heng Shen, Lei Shan, Hui-Zi Jin*, Qing-Yan Sun, and Wei-Dong Zhang. Construction of 2‑Substituted-3-Functionalized Benzofurans via Intramolecular Heck Coupling: Application to Enantioselective Total Synthesis of Daphnodorin B. Org. Lett., 15(18): 4742-4745 (2013).
17. Jiang-Jiang Qin, Ying Huang, Dan Wang, Xiang-Rong Cheng, Qi Zeng, Shou-De Zhang, Zhen-Lin Hu, Hui-Zi Jin* and Wei-Dong Zhang*. Lineariifolianoids A–D, rare unsymmetrical sesquiterpenoid dimers comprised of xanthane and guaiane framework units from Inula lineariifolia. RSC Adv., 2: 1307-1309 (2012).
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