新萄京网址33522

 

师资队伍

师资队伍
师资队伍

姜发琴

副教授

 

电话:021-34204787
邮箱: jfq2008@sjtu.edu.cn
主页:新萄京网址335227号楼-500室

博士,硕士生导师,药物化学方向

主要教育背景及科研经历:
2013年1月—至今 上海交通大学 副教授
2008年3月—2012年12月 上海交通大学 助理研究员
2009年3月—2011年3月 美国德州大学奥斯汀分校 生物工程系 博士后
2007年3月—2008年3月 上海睿智化学有限公司 课题组长
2004年1月—2007年3月 浙江大学新萄京网址33522 博士
2001年9月—2004年1月 中国矿业大学化工学院 硕士
1997年9月—2001年6月 中国矿业大学化工学院 学士

主持或参加的主要科研项目
1. 企业合作课题,靶向Kras的抗肿瘤药物的开发,150万,2020年-2022年,主持,在研
2. 国家重点研发计划“蓝色粮仓科技创新”重点专项,2019YFD0901902,基于水产复杂底物的多酶级联及反应分离耦合关键技术,24万, 2020/01-2022/12,子课题,在研
3. 医工合作项目, PS-A多囊脂质体对RDS肺泡巨噬细胞焦亡调控机制的研究, 2017年-2020年,合作主持,在研
4. 国家自然科学基金青年基金,81202397, 以3M-Sortase A 蛋白酶为靶点的抗感染药物的设计,合成及活性研究,23万,2013/01-2015/12,主持,结题
5. 上海市自然科学基金,12ZR1415400,新型苯并呋喃类Sortase A抑制剂的设计、合成及抗感染活性研究,10万,2012/07-2015/06,主持,结题
6.医工合作项目,新型长效胰高血糖素样肽GLP-1类似物的设计、合成及降糖活性研究, 2016年-2018年,合作主持,已结题
7.新型长效胰高血糖素样肽GLP-1类似物的设计、合成及降糖活性研究,新萄京网址33522,2018年-2019年,主持,已结题



新型药物分子的开发及作用机制研究:
1)新型抗肿瘤药物的研发
2、 新型抗感染药物的研发
3、 新型抗糖尿病药物的研发
1. Jian Shen#, Xinxian Deng#, Ran Sun, Mojdeh S. Tavallaie, Juntao Wang, Qingqing Cai, Celine Lam, Shuwen Lei, Lei Fu,* and Faqin Jiang,*. Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors. European Journal of Medicinal Chemistry, 2020, accepted.(IF=5.57)
2.Shuwen Lei, Dongdong Zhang, Yunyue Qi, Sharmin Reza Chowdhury, Ran Sun, Juntao Wang, Hui Zhu, Yi Du, Lei Fu* and Faqin Jiang*, Synthesis and Biological Evaluation of Geniposide derivatives as potent and selective PTPlB inhibitors, European Journal of Medicinal Chemistry, 2020, 205:112508-112520 (IF=5.57)
3. XX Deng, M S. Tavallaiea, R Sun, JT Wang, QQ Cai, J Shen, SW Lei, L Fu⁎, FQ Jiang⁎, Drug discovery approaches targeting the incretin pathway. Bioorganic Chemistry, 2020, 99: 103810.(IF=4.83)
4. M. Tavallaie, R. Voshtani, X. Deng, Y. Qiao, F. Jiang, J. P. Collman, L. Fu, Moderation of Mitochondrial Respiration Mitigates Metabolic Syndrome of Aging. Proc. Natl. Acad. Sci., (2020), 117(18), 9840-9850. (IF=9.41)
5. R Sun, XX Deng; DD Zhang; FZ Xie; D Wang; JT Wang; M S Tavallaie, FQ Jiang*, L Fu *, Anti-diabetic potential of Pueraria lobata root extract through promoting insulin signaling by PTP1B inhibition. Bioorganic Chemistry, 2019, 87: 12-15.(IF=4.83)
6. XX Deng, J Shen, H Zhu, J Xiao, R Sun, FZ Xie, C Lam, JT Wang, YX Qiao, M S Tavallaie, Y Hu, Y Du, JQ Li, L Fu*, FQ Jiang*, Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors. Bioorganic & Medicinal Chemistry, 2018, 2018(26): 903-912.(IF=3.07)
7. Qiao, Yixue; Dsouza, Charlotte; Matthews, Abigail Ann; Jin, Yan; He, Wan; Bao, Jian; Jiang, Faqin; Chandna, Ritu; Ge, Ruowen; Fu, Lei. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy, European Journal of Medicinal Chemistry (2020), 193, 112228. (IF=5.57)
8. Li, Liang; Tavallaie, Mojdeh S.; Xie, Fangzhou; Xia, Yu; Liang, Yaoyao; Jiang, Faqin; Fu, Lei, Identification of lipid-​like salicylic acid-​based derivatives as potent and membrane-​permeable PTP1B inhibitors, Bioorganic Chemistry (2019), 93, 103296. (IF=4.83)
9. Xie, Fangzhou; Liang, Yaoyao; Xia, Yu; Luo, Shuhua; Jiang, Faqin; Fu, Lei, Discovery of 2-​ethoxy-​4-​(methoxymethyl)​benzamide derivatives as potent and selective PTP1B inhibitors,Bioorganic Chemistry (2019), 92, 103273. (IF=4.83)
10. Xie, Fangzhou; Yang, Fengzhi; Liang, Yaoyao; Li, Liang; Xia, Yu; Jiang, Faqin; Liu, Wenlu; Qi, Yunyue; Chowdhury, Sharmin Reza; Xie, Dongsheng; et al, Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors, European Journal of Medicinal Chemistry (2019), 164, 408-422. (IF=5.57)
11. Burkholder, Nathaniel Tate; Mayfield, Joshua E.; Yu, Xiaohua; Irani, Seema; Arce, Daniel K.; Jiang, Faqin; Matthews, Wendy L.; Xue, Yuanchao; Zhang, Yan Jessie, Journal of Biological Chemistry (2018), 293(43), 16851-16861.(IF=4.11)
12. Zhang, Wei; Liu, Jingbao; Macho, Jocelyn M.; Jiang, Xizhen; Xie, Dongsheng; Jiang, Faqin; Liu, Wenlu; Fu, Lei, Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives, Journal of Chemical and Pharmaceutical Research (2016), 8(10), 130-140.
13. Yang, Fengzhi; Xie, Fangzhou; Zhang, Ying; Xia, Yu; Liu, Wenlu; Jiang, Faqin; Lam, Celine; Qiao, Yixue; Xie, Dongsheng; Li, Jianqi; et al, Y-​shaped bis-​arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors, Bioorganic & Medicinal Chemistry Letters (2017), 27(10), 2166-2170.(IF=2.57)
14. Y Zhang, J Bao, XX Deng, W He, JJ Fan, FQ Jiang*, L Fu, Synthesis, Biological Evaluation and Molecular Docking of 2-Phenyl-Benzo[d]oxazole-7-Carboxamide Derivatives as Potential Staphylococcus aureus Sortase A Inhibitors. Bioorganic & Medicinal Chemistry Letters, 2016,26:4081-4085.(IF=2.57)
15. W He, J Bao,Y Zhang, XX Deng, JJ Fan, FQ Jiang*, L Fu,Synthesis, Biological Evaluation and Molecular Docking Analysis of 2-phenyl-benzofuran-3-carboxamide derivatives as Potential Inhibitors of Staphylococcus aureus Sortase A, Bioorganic & Medicinal Chemistry, 2016, 25: 1341-1351. (IF=3.05)
16. Liu, Wenlu; Jiang, Xizhen; Zhang, Wei; Jiang, Faqin; Fu, Lei,Synthesis and antibacterial activity study of C-​3 α,​β-​unsaturated ketone linked benzofuran derivatives, Organic Chemistry: Current Research (2016), 5(1), 164/1-164/7.
17. Zhang, Wei; Liu, Jingbao; Macho, Jocelyn M.; Jiang, Xizhen; Xie, Dongsheng; Jiang, Faqin; Liu, Wenlu; Fu, Lei, Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives, European Journal of Medicinal Chemistry (2017), 126, 7-14. (IF=5.57)
18. He, Wan; Xu, Buzhe; Bao, Jian; Deng, Xinxian; Liu, Wenlu; Zhang, Yong; Jiang, Faqin; Fu, Lei, Synthesis and antimicrobial evaluation of 3-​substituted-​imine-​6-​hydroxy-​benzofuran derivatives, Medicinal Chemistry Research (2016), 25(11), 2485-2497.(IF=1.78)
19. Deng, Xinxian; Liu, Jingbao; Jin, Yan; Zhang, Yong; He, Wan; Bao, Jian; Liu, Wenlu; Jiang, Faqin; Fu, Lei, Identification of 2-​substituted ethenesulfonic acid ester derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatase 1B, Pharmazie (2015), 70(12), 777-783.(IF=1.19)
20. Jin, Yan; Cheng, Xueheng; Jiang, Faqin; Guo, Zheng; Xie, Jin; Fu, Lei, Application of the ultrafiltration-​based LC-​MS approach for screening PTP1B inhibitors from Chinese red yeast rice, Analytical Methods (2016), 8(2), 353-361.(IF=2.596)
21. Liu, Jingbao; Deng, Xinxian; Jin, Yan; Xu, Buzhe; Liu, Wenlu; Jiang, Faqin; Fu, Lei, Design, synthesis, and biological evaluation of 2-​substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors, Pharmazie (2015), 70(7), 446-451.(IF=1.20)
22. Xiang, Liang; Moncivais, Kathryn; Jiang, Faqin; Willams, Blake; Alfonta, Lital; Zhang, Zhiwen J., Crucial optimization of translational components towards efficient incorporation of unnatural amino acids into proteins in mammalian cells, PLoS One (2013), 8(7), e67333.(IF=2.74)
23.Zhu, Jie; Xiang, Liang; Jiang, Faqin; Zhang, Zhiwen J.Equilibrium of sortase A dimerization on Staphylococcus aureus cell surface mediates its cell wall sorting activity,Experimental Biology and Medicine (London, United Kingdom) (2016), 241(1), 90-100. (IF-3.14)
24. JB Liu, FQ Jiang*, Y Jin, JJ Liu, WL Liu, and L Fu, Design, synthesis, and evaluation of 2-substituent ethenesulfonic acid ester derivatives as novel protein tyrosine phosphatase 1B inhibitors, European Journal of Medicinal Chemistry, 2012, 57, 10-20.(IF=5.57)
25. JB Liu1, FQ Jiang1, XZ Jiang, W Zhang, JJ Liu, WL Liu, L Fu, Synthesis and antimicrobial evaluation of 3-methanone-6-substituent-benzofuran derivatives, European Journal of Medicinal Chemistry, 2012, 54 , 879-886(IF=5.57)
26. Zhang, Wei; Liu, Wenlu; Jiang, Xizhen; Jiang, Faqin; Fu, Lei, One-​pot synthesis of hydroxybenzo[d]​oxazole-​2-​aliphatic acid derivatives by Meerwein's reagent, Synthetic Communications (2012), 42(18), 2772-2779.(IF=1.80)
27. XZ Jiang, WL Liu, W Zhang, FQ Jiang, L Fu, Synthesis and antimicrobial evaluation of new benzofuran derivatives, European Journal of Medicinal Chemistry, 2011, 46, 3526-3530.(IF=5.57)
28. Aiko Umeda, GN Thibodeaux, K Moncivais, FQ Jiang and Z J Zhang. A versatile approach to transform low-affinity peptides into protein probes with cotranslationally expressed chemical cross-linker. Anal Biochem. 2010,405(1), 82-88.(IF=2.88)
授权专利:
1.傅磊,姜发琴,徐步哲,包健,何宛,张勇;苯并呋喃类化合物及其制备、用途,专利号:CN201410753236.2
2.傅磊,姜发琴,包健,张勇,何宛,邓新贤;苯并恶唑类化合物及其制备方法和用途;专利号:205101319983
3. 傅磊,姜发琴,何宛,张勇,邓新贤,郭秋圆; 苯并呋喃类化合物及其制备方法和应用,专利号:CN201510657959.7
4.傅磊,谢方洲,杨凤志,谢东升,姜发琴,亓云月,李亮 ,张赢,郭秋圆,孙冉,俞骥昊 ,一种新型PTP1B酶抑制剂及其制备方法和应用,CN201710160612.0
5.傅磊,邓欣贤,姜发琴,肖佳,沈坚,朱惠,一种DPP-4酶抑制剂及其制备和应用,专利号:CN201710440040.1
6.傅磊,张赢,杨凤志,谢方洲,邓欣贤,乔祎雪,姜发琴,谢东升;一种新型乙酰胆碱酯酶抑制剂及其制备方法和应用,专利号:CN201710818243.X
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